How To Clear Histamine From Body

Histamine, a naturally occurring compound in the body, plays a crucial role in the immune system, aiding in the body's defense against allergens and pathogens. However, too much histamine can lead to uncomfortable and sometimes severe symptoms, a condition known as histamine intolerance. Symptoms can range from headaches and hives to digestive and respiratory problems, significantly impacting one's quality of life.

For those struggling with histamine intolerance, finding effective ways to clear excess histamine from the body is essential for restoring balance and improving health. This comprehensive guide will explore strategies to manage and reduce histamine levels naturally. We will delve into dietary changes, beneficial supplements, lifestyle modifications, and innovative remedies like CBD, which has shown promise in helping to regulate histamine levels.

Whether you're just beginning to understand histamine intolerance or seeking new methods to manage it, this guide will provide you with the knowledge and tools needed to take control of your health. From understanding the basics of histamine and its effects on the body to implementing practical solutions, we aim to offer a holistic approach to developing histamine intolerance management.

Join us as we explore how to clear out histamine further from the body and embrace a healthier, more balanced life. 

What is Histamine?


Definition and Function in the Immune System

Histamine is a biogenic amine, a naturally occurring chemical in the body which opens up your blood vessels that is involved in the immune and allergic response, regulating physiological function in the gut, and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is stored primarily in mast cells and basophils, types of white blood cells, and is released during the immune response to allergic reactions or injury. Mast cells are a type of white blood cell that's present in connective tissues throughout your body.

How Histamine Affects the Body

White blood cells emit histamine, which attaches to histamine receptors found all over the body. This interaction leads to histamine reactions to a variety of physiological responses, including:

Inflammation and Swelling

Inflammation and Swelling: Histamine causes blood vessels to dilate and become more permeable, allowing immune cells to access affected tissues more easily. This results in the redness and swelling associated with allergic reactions.

Smooth Muscle Contraction

Smooth Muscle Contraction: In the lungs, high levels of histamine can cause the smooth muscles to contract, leading to symptoms like bronchoconstriction in asthma.

Gastric Acid Secretion

Gastric Acid Secretion: Histamine stimulates the production of stomach acid, aiding in digestion but potentially causing issues like acid reflux when overproduced.


Neurotransmission: In the brain, histamine acts as a neurotransmitter, influencing wakefulness, appetite, and cognitive function.

Common Sources of Histamine

Histamine is not only produced by the body but also ingested through certain foods and influenced by environmental factors. Common sources that trigger histamine release in your body include: 

High Histamine Foods

  • Fermented foods (e.g., sauerkraut, kimchi)

  • Aged cheeses

  • Cured meats (e.g., salami, ham)

  • Alcoholic beverages (e.g., wine, beer)

  • Certain vegetables (e.g., tomatoes, spinach)

  • Seafood (e.g., tuna, mackerel)

Environmental Factors

  • Pollen and mold spores

  • Dust mites

  • Animal dander

  • Insect stings

Understanding Histamine Intolerance

Histamine Intolerance

What is Histamine Intolerance?

Histamine intolerance originates in the gut. An imbalance between the body's ability to break down histamine and the quantity that is consumed or created therein results in histamine intolerance. Normally, the enzyme diamine oxidase (DAO) in the digestive tract and histamine N-methyltransferase (HNMT) in the liver degrade histamine efficiently. However, unavoidable histamine alone, when these enzymes are deficient or overwhelmed, accumulates, leading to a variety of symptoms.

Causes of Histamine Intolerance

Several factors can contribute to histamine intolerance, including:

Enzyme Deficiency: Reduced activity or levels of DAO and HNMT enzymes, which can be due to genetic factors, chronic disease, or certain medications that inhibit these enzymes.

Excessive Histamine Intake: Consuming large amounts of histamine-rich foods or beverages.

Gut Health Issues: Conditions like leaky gut syndrome, irritable bowel syndrome (IBS), and small intestinal bacterial overgrowth (SIBO) can impair the breakdown of histamine.

Impaired Metabolism: Liver dysfunction or other metabolic issues can reduce the body's ability to process and clear histamine.

Symptoms and Signs of Histamine Intolerance

Histamine intolerance can manifest in a wide range of symptoms that often mimic allergic reactions. These inflammatory disorders can affect various systems in the body, including:

Gastrointestinal Symptoms

  • Abdominal pain

  • Bloating

  • Diarrhea

  • Nausea and vomiting

Respiratory Symptoms

  • Nasal congestion or runny nose

  • Difficulty breathing

  • Wheezing

Skin Symptoms

  • Hives

  • Itching

  • Flushing or redness

Neurological Symptoms

  • Headaches or migraines

  • Dizziness

  • Anxiety

  • Fatigue

Cardiovascular Symptoms

  • Heart palpitations

  • Low blood pressure

Diagnosing Histamine Intolerance

Diagnosing histamine intolerance can be challenging due to the wide range of symptoms and their overlap with other conditions. Common diagnostic methods include:

Blood Tests: Measuring histamine levels and DAO enzyme activity in the blood.

Elimination Diet: Removing high-histamine foods from the diet for several weeks and then reintroducing them to observe symptoms.

Symptom Tracking: Keeping a detailed food diary of symptoms, dietary intake, and environmental exposures to identify patterns.

CBD as a Remedy for Histamine Clearance

What is CBD?

CBD, or cannabidiol, is a natural compound found in the cannabis plant. Unlike THC (tetrahydrocannabinol), the psychoactive component of cannabis, CBD does not produce a "high." It has gained popularity for its potential therapeutic benefits, including anti-inflammatory, analgesic, and anxiolytic properties.

How CBD Helps with Histamine Clearance

CBD interacts with the endocannabinoid system (ECS) in the body, which is important for controlling inflammation and the immune system, among other physiological activities. Here’s how CBD can help manage histamine levels:

Anti-Inflammatory Properties: CBD is known for its strong anti-inflammatory effects, which can help reduce the inflammation associated with high histamine levels.

Immune System Modulation: CBD can modulate the immune system, potentially preventing the excessive release of histamine from mast cells.

Interaction with Endocannabinoid System: The ECS helps maintain homeostasis in the body. By interacting with ECS receptors, CBD can help balance immune and inflammatory responses and reduce histamine release.

Studies and Research on CBD and Histamine Levels

Research on CBD's effects on histamine levels and allergic reactions is still emerging. Some studies suggest that CBD may help reduce the release of histamine from mast cells, thereby mitigating allergic responses and symptoms associated with people with histamine intolerance alone. However, more clinical trials are needed to fully understand its efficacy and mechanisms.

Using CBD for Histamine Intolerance

When considering CBD as a remedy for histamine intolerance, it’s important to choose the right form and dosage:

Recommended Forms of CBD

CBD is available in various forms, each with its own benefits.

Alive Market CBD Oil

CBD Oil: Can be taken sublingually for quick absorption or added to food and drinks.

Alive Market Full Spectrum CBD Capsules

CBD Capsules: Provide a convenient and precise dosage.

Alive Market 750mg CBD Daily Gummies | Full Spectrum CBD

CBD Edibles: Such as gummies, offer a tasty and easy way to consume CBD.

Full Spectrum CBD Body Butter

Topical CBD: Creams and balms can be applied to the skin to reduce localized inflammation.

Dosage Guidelines and Considerations

Starting with a low dose and gradually increasing is advisable. Common starting doses range from 10 to 20 mg per day. It's important to consult with a healthcare provider to determine the appropriate dosage based on individual health needs and conditions.

Potential Side Effects and Precautions

While CBD is generally well-tolerated, some people may experience side effects, including:

Dry Mouth: Staying hydrated can help alleviate this.

Drowsiness: Taking CBD in the evening can mitigate this effect.

Interactions with Medications: CBD can interact with certain medications, so it’s important to discuss its use with a healthcare provider.

Natural Ways to Clear Histamine from the Body

Diet and Nutrition

Diet and Nutrition

Proper diet and nutrition play a crucial role in managing and clearing histamine levels in the body. Here are some dietary strategies to help clear and raise histamine levels:

Low-Histamine Diet: Foods to Avoid

Certain foods are known to be high in histamine or to otherwise trigger symptoms of histamine release or its release. Avoiding these can help manage symptoms:

Fermented Foods: Sauerkraut, kimchi, yogurt, and pickles

Aged Cheeses: Cheddar, gouda, and parmesan

Cured Meats: Salami, ham, and sausages

Alcoholic Beverages: Wine, beer, and champagne

Certain Vegetables: Tomatoes, spinach, and eggplant

Seafood: Tuna, mackerel, and sardines

Low-Histamine Diet: Foods to Include

Opting for low-histamine foods can help reduce the overall histamine load:

Fresh Meat and Fish: Chicken, turkey, fresh-caught fish

Certain Vegetables: Carrots, zucchini, and cauliflower

Fruits: Apples, pears, and watermelon (except citrus fruits)

Grains: Rice, quinoa, and oats

Dairy Alternatives: Plant-based milk and cheeses

Anti-Inflammatory Foods and Their Benefits

Incorporating anti-inflammatory foods can help manage histamine levels by reducing inflammation and supporting overall health.

Omega-3 Fatty Acids: Found in fish oil, flaxseeds, and chia seeds

Turmeric: Contains curcumin, a powerful anti-inflammatory compound

Ginger: Helps reduce inflammation and aids digestion

Leafy Greens: Such as kale, spinach, and arugula

Role of Hydration in Managing Histamine Levels

Staying well-hydrated is essential for overall health and can help manage histamine levels. Water helps flush out toxins and supports optimal digestive function, aiding in the breakdown and elimination of histamine.

Supplements and Vitamins

Supplements and Vitamins

Certain supplements and vitamins can support the body in breaking down and managing histamine:

Vitamin C: Benefits and Sources

Vitamin C acts as a natural antihistamine by breaking down histamine and reducing its levels in the blood. Rich sources include:

Citrus Fruits: Oranges, lemons, and grapefruits

Berries: Strawberries, raspberries, and blueberries

Bell Peppers: Red, green, and yellow varieties

Quercetin: Benefits and Sources

Quercetin is a flavonoid that has natural antihistamine and anti-inflammatory properties. It can be found in:

Fruits: Apples and berries

Vegetables: Onions and capers

Herbs: Dill and cilantro

DAO Enzyme Supplements: How They Work and Usage

DAO enzyme supplements can help break down histamine in the digestive tract, reducing symptoms of histamine intolerance. These supplements are particularly useful for those with DAO deficiency. These treat heart rhythm irregularities antihypertensives, which treat high blood pressure muscle relaxants narcotics local anesthetics They should be taken before meals to aid in the digestion of histamine-containing foods.

Lifestyle Changes

Lifestyle Changes

Implementing certain lifestyle changes can also help manage histamine levels and alleviate symptoms:

Stress Management Techniques

Stress can exacerbate histamine intolerance by triggering the release of histamine. Stress triggers the release of histamine and can worsen allergy symptoms and allergic reactions. Effective stress management techniques include:

Meditation: Helps calm the mind and reduce stress

Yoga: Combines physical activity with relaxation techniques

Breathing Exercises: Promote relaxation and reduce stress-induced histamine release

Regular Exercise and Its Impact on Histamine Levels

Moderate, regular exercise can help manage histamine levels by reducing inflammation and supporting overall health. However, it's important to avoid over-exercising, which can increase histamine release.

Importance of Sleep and Its Effect on Histamine

Quality sleep is essential for overall health and helps regulate histamine levels. Establishing a regular sleep routine and creating a relaxing sleep environment can improve sleep quality and reduce symptoms.

Additional Remedies for Managing Histamine Levels

Herbal Remedies

Herbal remedies can offer natural ways to help manage histamine levels and alleviate symptoms of histamine intolerance. Here are some commonly used herbs:

Common Herbs for Histamine Management

Stinging Nettle: Known for its anti-inflammatory properties, stinging nettle can help reduce histamine levels and alleviate allergy symptoms.

Butterbur: This herb has been shown to reduce the release of histamine and can be effective in managing allergy symptoms, like headaches and nasal congestion.

Chamomile: Known for its calming effects, chamomile can help reduce inflammation and soothe digestive issues related to histamine intolerance.

How to Incorporate Herbs into Your Routine

Herbal Teas: Drinking herbal teas made from stinging nettle, chamomile, or butterbur can provide a gentle and effective way to manage histamine levels.

Herbal Supplements: Capsules or tinctures containing these herbs can be taken as supplements. Follow the recommended dosages on the packaging or consult with a healthcare provider.

Cooking with Herbs: Incorporate these herbs into your cooking. For example, add chamomile flowers to your salads or use stinging nettles in soups.

Probiotics and Gut Health

Maintaining a healthy gut is essential for managing histamine levels, as a significant portion of histamine is processed in the digestive system. Probiotics can support gut health and help balance histamine levels.

Role of Gut Health in Histamine Management

A healthy gut microbiome aids in the breakdown of histamine. Gut health issues, such as leaky gut syndrome or dysbiosis, can impair this process and contribute to histamine intolerance.

Best Probiotics for Histamine Intolerance

Certain probiotic strains can help reduce histamine production and support gut health:

Lactobacillus rhamnosus: Known for its ability to degrade histamine.

Bifidobacterium infantis: Helps reduce inflammation and supports gut health.

Lactobacillus plantarum: Can help lower histamine levels and improve gut function.

Incorporating Fermented Foods and Probiotics into Your Diet

Fermented Foods: Foods like kefir, kimchi, and sauerkraut can be beneficial for gut health but may be high in their histamine content. Opt for freshly made, low-histamine versions if possible.

Probiotic Supplements: Taking a daily probiotic supplement with the strains mentioned above can support gut health and histamine management.

Environmental Controls

Reducing exposure to environmental allergens and improving indoor air quality can help manage histamine levels and reduce symptoms allergic asthma.

Reducing Exposure to Environmental Allergens

Pollen and Dust: Use air purifiers with HEPA filters to reduce pollen and dust in your home.

Pet Dander: Regularly bathe and groom pets to minimize dander. Use air purifiers to reduce airborne allergens.

Mold: Keep humidity levels in check and address any water leaks or mold growth promptly.

Improving Indoor Air Quality

Air Purifiers: Invest in high-quality air purifiers to reduce allergens and pollutants in your home.

Ventilation: Ensure proper ventilation to reduce the buildup of indoor allergens.

Houseplants: Some houseplants can help improve air quality by filtering out toxins. Consider plants like spider plants, snake plants, and peace lilies.

When to Seek Medical Advice

Managing histamine intolerance often involves a combination of dietary changes, lifestyle adjustments, and natural remedies. However, it's important to recognize when to seek medical advice for more comprehensive care and guidance.

Identifying Severe Symptoms

If you develop signs of seasonal allergies or an allergic reaction, reach out to your provider, especially if your symptoms are affecting your daily functioning. Certain symptoms of histamine intolerance may indicate a more serious underlying condition or require medical intervention. These include:

Severe Allergic Reactions: Such as anaphylaxis, are characterized by difficulty breathing, swelling of the throat or tongue, and a rapid pulse. This is a medical emergency requiring immediate attention.

Persistent Symptoms: If symptoms persist despite dietary changes and natural remedies, it's essential to consult with a healthcare provider to rule out other conditions.

Digestive Issues: Chronic abdominal pain, severe diarrhea, or persistent nausea and vomiting may indicate gastrointestinal disorders that require medical evaluation.

Respiratory Symptoms: Chronic cough, wheezing, or shortness of breath could be signs of asthma or other respiratory conditions that need medical assessment.

Skin Reactions: Persistent hives, itching, or swelling of the skin may require a medical evaluation to determine the underlying cause of the allergic reaction and appropriate treatment.

Treatment Options from Healthcare Professionals

Healthcare providers, such as allergists, immunologists, and gastroenterologists, can offer specialized care and treatment options for histamine intolerance:

Allergy Testing: Comprehensive allergy testing can help identify specific allergens triggering histamine release and guide avoidance strategies.

Medications: Antihistamines and other medications may be prescribed to manage symptoms and reduce histamine levels.

Dietary Counseling: Registered dietitians can provide personalized dietary recommendations and guidance on implementing a low-histamine diet.

Supplements: Healthcare providers may recommend specific supplements, such as DAO enzyme supplements, based on individual needs and deficiencies.

Management of Underlying Conditions: Addressing underlying conditions contributing to histamine intolerance, such as gut health issues or immune system disorders.

Long-Term Management Strategies

Developing long-term management strategies is crucial for effectively controlling histamine intolerance and improving quality of life:

Lifestyle Modifications: Implementing stress management techniques, regular exercise, and adequate sleep can help reduce histamine levels and support overall health.

Monitoring Symptoms: Keeping a symptom diary can help track triggers and identify patterns, facilitating adjustments to your management plan.

Regular Follow-Ups: Schedule regular follow-up appointments with healthcare providers to monitor progress, adjust treatment plans as needed, and address any new concerns.

By seeking medical advice and working closely with healthcare professionals, individuals with histamine intolerance can receive comprehensive care, personalized treatment strategies, and support in effectively managing their condition.


Managing histamine intolerance requires a multifaceted approach that combines dietary adjustments, lifestyle modifications, natural remedies, and, when necessary, medical guidance. By understanding the role of histamine in the body, identifying histamine triggers, and implementing effective strategies, individuals can effectively reduce histamine levels and alleviate symptoms.

Throughout this comprehensive guide, we've explored various methods to naturally clear out histamine from the body:

CBD as a Remedy: Understanding how CBD interacts with the endocannabinoid system to potentially reduce histamine release.

Diet and Nutrition: Adopting a low-histamine diet, incorporating anti-inflammatory foods, and staying hydrated.

Supplements and Vitamins: Utilizing vitamin C, quercetin, and DAO enzyme supplements to support histamine metabolism.

Lifestyle Changes: Implementing stress management techniques, regular exercise, and prioritizing quality sleep.

Additional Remedies: Exploring herbal remedies like stinging nettles and probiotics to support gut health and manage histamine levels.

Each individual may respond differently to treatments, so it's important to tailor approaches based on personal preferences and healthcare provider recommendations. Regular monitoring of symptoms and adjustments to the management plan can help achieve long-term relief and improve overall well-being.

People can restore control over their health and live better lives by controlling the symptoms of histamine intolerance proactively. Always remember to consult with healthcare professionals for personalized advice and guidance tailored to your specific needs and health conditions.

Embrace these strategies, stay informed, and empower yourself in the journey to clear histamine from your body and achieve optimal health.

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